Protein Details: Gamma-aminobutyric acid receptor-associated protein-like 1

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane; the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264; participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress; which then fuse with lysosomes for endoplasmic reticulum turnover.

Sequence

PDB Structures

Ligand Binding